Self-organization in the cell relies on the rapid and specific binding of molecules to their cognate targets.Correct bindings must be stable enough to promote the desired function even in the crowded and fluctuating cellular environment.In systems with many nearly matched targets, rapid and stringent formation of stable products is challenging.Mech
Identifying New Knowledge Areas to Strengthen the Project Management Institute (PMI) Framework
In an increasingly volatile, uncertain, complex and ambiguous (VUCA) world, managers of capital projects are under relentless pressure to consistently meet their performance expectations.At the execution stage, managers have to constantly orchestrate competing demands on scare resources and, simultaneously, manage project operations to meet time, c
Production of succinate by engineered strains of Synechocystis PCC 6803 overexpressing phosphoenolpyruvate carboxylase and a glyoxylate shunt
Abstract Background Cyanobacteria are promising hosts for the production of various industrially important compounds such as succinate.This study focuses on introduction of the glyoxylate shunt, which is naturally present in only a few cyanobacteria, into Synechocystis PCC 6803.In order to test its impact on cell metabolism, engineered strains were